Avana™ 100 MG Avanafil Tablets (Generic Stendra)

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Avana™ 100 MG Avanafil is a strong, highly selective, reversible phosphodiesterase type 5 (PDE5) inhibitor with specificity for cyclic guanosine monophosphate (cGMP). After local release of nitric oxide occurs as a result of sexual stimulation, inhibition of PDE5 by avanafil causes an increase in cGMP concentration in the cavernous bodies of the penis. This leads to relaxation of the smooth muscles and blood flow into the tissues of the penis, thus causing an erection. The effect of avanafil does not develop in the absence of sexual stimulation.

• The effect of Avana™ 100 MG lasts from six hours or more. This is the most optimal time to have a lot of fun.
• Unlike other similar drugs, Avana™ 100 MG can be used by men of different ages, even older ones, if they show interest in sex. Do not interfere with the work of the liver and kidneys.

What Are The Benefits Of Avana™ 100 MG?

It hardly needs to be explained that the faster the pill works, the more it provides spontaneity, sexual unpredictability. Just 15 minutes after the reception – and you will feel strong and fully prepared for it. If Avana™ 100 MG becomes your constant companion, then the onset of action will become even shorter, since Avanafil has the correct accumulation rate in the body.

Those who understand the charm of a romantic feast before sex will appreciate the importance of another advantage of Avana™ 100 MG – the possibility of taking it with alcohol and fatty foods.

Using Avana™ 100 MG Avanafil

Use in adult men

• For oral administration. When taking the drug Avana™ 100 MG during meals, the onset of action may be delayed compared to taking it on an empty stomach.
• The recommended dose of 100 mg is taken as needed, approximately 15-30 minutes before sexual activity.
• Depending on individual efficacy and tolerability, the dose can be increased to a maximum of 200 mg or reduced to 50 mg.
• The maximum recommended frequency of use is 1 time per day.
• Sexual stimulation is necessary to achieve a response to taking the drug.

Special patient groups

Older men (age >65 years)

• Dose adjustment when using the drug in elderly patients is not required. Data on the use of Avana™ 100 MG in elderly patients aged 70 years are limited.

Patients with impaired renal function

• Dose adjustment in patients with mild to moderate renal insufficiency (creatinine clearance 30 ml/min) is not required.
• The use of Avana™ 100 MG is contraindicated in patients with severe renal impairment (creatinine clearance <30 ml/min). In patients with mild to moderate renal impairment (creatinine clearance30 ml /min, but <80 ml/min), who participated in phase III studies, the effectiveness of the drug was lower than in patients with normal renal function.

Patients with impaired liver function

• The use of Avana™ 100 MG is contraindicated in patients with severe hepatic impairment (class C on the Child-Pugh scale). In patients with mild or moderate hepatic impairment (classes A or B on the Child-Pugh scale), treatment should be started with the minimum effective dose and adjusted depending on tolerability.

Use in men with diabetes mellitus

• Dose adjustment when using Avana™ 100 MG in patients with diabetes mellitus is not required.

Children’s patients

• Avana™ 100 MG is not intended for use in children.

Use in patients taking other medications

• Simultaneous use of CYP3A4 isoenzyme inhibitors
• Concomitant use of Avana™ 100 MG and strong inhibitors of the CYP3A4 isoenzyme (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin) is contraindicated.
• In patients receiving concomitant therapy with moderate inhibitors of the CYP3A4 isoenzyme (including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir and verapamil), the maximum recommended dose of avanafil should not exceed 100 mg, and the interval between doses should be at least 48 hours.

How Long Does The Effect Last?

The first question that arises before using the Avana™ 100 MG drug: how long does it work?

This is undoubtedly important, because any further development of events depends on it.

Thus, avanafil is considered one of the fastest ways to improve potency. In many studies, men had an erection sufficient for sexual intercourse already 15 minutes after taking the drug, while the drug reaches its maximum effectiveness after 30-45 minutes.

Not bad results, right?

However, Avana™ 100 MG is not an aphrodisiac and sexual arousal is necessary for its action.

Action Time

After the active components have entered the bloodstream, the substance remains in the body for a long time. The average half-life is about 3 to 5 hours. The action of the drug remains effective for about 6 hours.

Contraindications

Before any use of the drug, you should study its instructions and find out the contraindications of  Avana™ 100 MG. It is forbidden to use the drug in such cases:

• patients who have recently (within the last 6 months) had a heart attack or stroke;
• minor patients;
• with hypersensitivity to any of the components of the drug;
• with high blood pressure levels;
• people with disorders of the cardiovascular system;
• patients with problems with the functioning of the kidneys.

If you are not sure about your health, you should consult a doctor!

Side effects

When using the drug, all kinds of side effects of  Avana™ 100 MG are not excluded.

But this can be easily avoided by adhering to the dosage prescribed by the doctor. Basically, adverse reactions are frivolous and transient in nature, among which the following are distinguished:

• headache, drowsiness, dizziness;
• increased photosensitivity, short-term visual impairment;
• violation of auditory receptors;
• increased heart rate, increased or decreased blood pressure;
• nasal congestion, increased shortness of breath after exercise;
• dry mouth, nausea, diarrhea;
• increased fatigue;
• insomnia, premature ejaculation.

However, all these side effects are rare and only occur in some men. To avoid the occurrence of these adverse reactions, you need to consult a competent doctor.

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